WebBIRC3 functions as an E3 ubiquitin ligase, polyubiqiutinating target proteins such as RIP kinases, caspases, TRAF1, and BCL10. Loss of BIRC3 results in a significant impairment of TNFα-mediated NF-κB activation signaling cascades. Product Details Technical data sheet Product Details Isotype Control Purified Rat IgG2a, κ Isotype Ctrl WebBaculoviral IAP repeat-containing protein3 (also known as cIAP2) is a protein that in humans is encoded by the BIRC3 gene. cIAP2 is a member of the inhibitor of …
BIRC3 definition of BIRC3 by Medical dictionary
WebDec 5, 2014 · The BIRC3 locus is 6 Mb centromeric to the ATM locus and >80% of patients with CLL and 11q22 deletion have also lost one allele of BIRC3. 10, 26 In addition, BIRC3 can be mutated in CLL cells at multiple loci that usually cause truncation of the BIRC3 protein and loss of E3 ubiquitin ligase activity. 10 Loss of one allele of BIRC3 by deletion … WebMar 22, 2012 · BIRC3, along with TRAF2 and TRAF3, cooperates in the same protein complex that negatively regulates MAP3K14, the central activator of noncanonical NF-κB signaling. 31-34 All inactivating mutations of BIRC3 detected in CLL are predicted to cause the elimination or truncation of the C-terminal RING domain, the E3 ubiquitin ligase … navyist rewards mastercard®
Gain of Additional BIRC3 Protein Functions through 3
WebMar 15, 2024 · BIRC3 loss-of-function mutations (BIRC3 mut) were detected in 4 of 111 patients with CLL, which resembled the reported frequency of 2% to 4% . Mutations were … WebMay 19, 2015 · BIRC3 is a member of the BIRC family, and apoptosis regulation is one of the important functions of their encoded proteins [19,20]. Furthermore, BIRC2, BIRC3 and TRAF2 had been identified as critical genes in the activation of NF-κB signaling in TNF pathways . At the same time, BIRC3 was observed to be significantly more up-regulated … WebSummary of BIRC3 (API2, c-IAP2, cIAP2, hiap-1, MALT2, MIHC, RNF49) expression in human tissue. Expression in several tissues, most abundant in subsets of immune cells. ... Mouse-over function shows protein score for analyzed cell types in a selected tissue. To access image data click on tissue name or bar. marks and spencer 25% off