Cisplatin and kidney damage

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August undefined, 2024

WebCisplatin (CP)-induced nephrotoxicity is widely accepted as a model for acute kidney injury (AKI). Although cisplatin-induced chronic kidney disease (CKD) in rodent has been reported, the role of phosphate in the cisplatin-induced CKD progression is not described. WebDec 3, 2024 · One in four patients treated with cisplatin develop chronic kidney disease. The Yale researchers found that by using an agonist peptide, derived from the secreted …

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WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe … WebOct 22, 2024 · As repeated injections of 6 mg/kg cisplatin in a one-week interval did not cause apparent kidney injury and those of 10 mg/kg cisplatin accelerated kidney injury without causing lethality,... list of engineering colleges in maharashtra

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WebDec 21, 2024 · Cisplatin is a potent first-line of chemotherapeutic drug for treating various neoplasms, but its administration in hospital settings is hampered due to its untoward nephrotoxicity. Previous investigations indicated that about 30% of cisplatin-treated patients (at the dose of 50–100 mg/m 2) developed AKI [ 7 ]. Webing on pathologic examination of human kidneys affected by cisplatin toxicity. Both proximal and distaltubulesareaffected,andinpatientswithAKI, there is usually acute tubular necrosis. Long-term cisplatin exposure may also cause cyst formation and interstitial ﬁbrosis (Figure 1) (3). Patients with cisplatin toxicity typically present WebCisplatin-induced kidney injury was mitigated by chemical inhibition of NLRP3 with MCC950, ... As opposed to immune-mediated CIT, the release of ROS occurs downstream in the signalling pathway of cisplatin-induced damage in healthy cells. Because the significance of ROS as the damage-causing agent has been established in CIT, it is only … imagination brass zoom zoom year release

Cisplatin nephrotoxicity: new insights and therapeutic …

Nephrotoxicity as a Dose-Limiting Factor in a High-Dose Cisplatin …

WebApr 25, 2014 · The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates dose reduction or withdrawal. Recurrent episodes of AKI may result in … WebAug 6, 2014 · The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates dose reduction or withdrawal. Recurrent episodes of AKI may result in chronic kidney disease. The pathophysiology of cisplatin-induced AKI involves proximal tubular injury, oxidative stress, inflammation, and vascular injury in the kidney. list of engineering colleges in puneWebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the development of AKI in patients with DM. MATE1/SLC47A1, an organic cation transporter in proximal tubular epithelial cells, mediates the tubular secretion of cationic drugs or … list of engineering colleges in india

"WebAug 24, 2024 · Damage to non-cancer cells can occur while the body works to metabolize and excrete the drug. “Although the body excretes 50% to 80% of the administered cisplatin within a day or so, some remains in the kidney, where it damages specific cells in the nephron, which removes waste from the blood before it is converted to urine,” Dr. Zhao … " - Cisplatin and kidney damage

Cisplatin and kidney damage

Cisplatin nephrotoxicity as a model of chronic kidney …

WebNov 12, 2024 · Peripheral Neuropathy: cisplatin injection can cause dose-related peripheral neuropathy.Nausea and Vomiting: cisplatin injection can cause severe … WebApr 12, 2024 · In the end, the kidney is heavily involved in the elimination of the drugs, and, as a consequence, kidney damage can lead to an altered excretion of the drugs and …

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WebCisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms … WebCisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can cause...

WebCisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, … WebMar 9, 2024 · Cisplatin is mainly excreted through the kidneys. It becomes concentrated during excretion, and the concentration in renal tubular epithelial cells is much higher …

WebApr 12, 2024 · The main risk factors related to the AKI onset in neoplastic patients are the (i) metabolic alterations associated with cancer (such as tumor lysis syndrome-TLS, uric acid nephropathy and hypercalcemia), (ii) the hematopoietic stem-cell transplantation (HSCT) that is often complicated by AKI, (iii) the use of nephrotoxic chemotherapeutic agents … WebMay 8, 2024 · Serum Creatinine (SCr)-Acute Kidney Injury (AKI) Staging Outlined by the Kidney Disease: Improving Global Outcomes (KDIGO) Guidelines and Electrolyte-AKI (eAKI) Grading Based on National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) Version 4 eTable 2.

WebThe prevalence of renal diseases including acute kidney injury (AKI) and chronic kidney disease (CKD) is increasing worldwide. However, the pathogenesis of most renal …

WebAlthough it is best known for DNA damage, cisplatin also causes cytoplasmic organelle dysfunction particularly with the endoplasmic reticulum and mitochondria. It also activates apoptotic pathways and inflicts cellular damage via oxidative stress and inflammation. One of its dose limiting toxicities is its effects on the kidney. imagination brand clothingWebFeb 16, 2016 · In cisplatin-based CCRT schedules, acute nephrotoxicity is commonly graded by an increase of serum creatinine levels, according to the Common Terminology Criteria for Adverse Events (CTCAE). Using these criteria nephrotoxicity ≥grade 3 occurs in only 4%–9% of patients [ 7, 10, 11 ]. imagination books for kidsWebwww.ncbi.nlm.nih.gov imagination box spongebob episodeWebCisplatin dose adjustment in patients with renal impairment must be improved. Estimating GFR with the aMDRD formula and adding an intermediary level of dose reduction for patients with eGFR from 50 to 59.9 mL/min may result in a higher cumulative dose of cisplatin without higher renal toxicity, whic … list of engineering colleges in nagpur pdfWebCisplatin and kidney damage Kent Cass Member Posts: 1,898 Member January 2010 edited March 2014 #1 The subject of kidney damage as a result of chemo by Cisplatin … imagination brokerageWebDec 2, 2024 · Cisplatin is a commonly used chemotherapeutic drug for cancer treatment, but its nephrotoxicity may lead to the deterioration of renal function. Previous work has … list of engineering colleges in tamil naduWebMay 8, 2024 · Nephrotoxicity With Cisplatin Patients may accumulate metabolites in the renal proximal tubule cells of the kidneys, where 90% of cisplatin undergoes urinary excretion, Duffy et al. explained. This causes a trifecta of factors: direct inflammation, production of reactive oxygen species leading to oxidative cell damage, and cell death. list of engineering colleges in navi mumbai