High dose statins in elderly

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WebManaging hypercholesterolemia and preventing cardiovascular events in elderly and younger Chinese adults: focus on rosuvastatin Zhen Wang, Junbo GeDepartment of Cardiology, Zhongshan Hospital, Shanghai, People's Republic of ChinaAbstract: Coronary heart disease (CHD) is the leading cause of death worldwide. The efficacy and safety of … Web3 de mar. de 2024 · Mechanism of action. The beneficial effects of statins result, at least in part, from direct inhibition of HMG-CoA reductase. Citation 8 This inhibition reduces endogenous cholesterol biosynthesis and increases the expression of LDL receptors responsible for LDL-C uptake and clearance. Citation 8 These do not seem to be the …

Prescribing statins to reduce cardiovascular risk - bpacnz

Web14 de abr. de 2024 · In the IMPROVE-IT trial, researchers showed adding ezetimibe to moderate-intensity statins vs. moderate intensity statin alone in ASCVD patients … WebPurpose: Although moderate- to high-intensity statin therapy is increasingly recommended in cardiovascular disease patients, the efficacy and safety in elderly … how to say cheers in hawaii

Safe use of statins in elderly people - Wiley Online Library

Web2 de fev. de 2024 · High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med. 2006; 355: 549-559. Crossref; PubMed; Scopus (2332) ... Benefits of statins in … Web18 de jun. de 2024 · The concentration of LDL cholesterol was 24 mg/dL lower in those taking the higher dose of atorvastatin, and the risk of having a major cardiovascular event was 22% lower ( P <0.001). But there was no significant effect on all-cause death. 3 In the IDEAL trial (Initiating Dialysis Early and Late), the effect of atorvastatin at a dose of 80 … Web29 de out. de 2024 · That's due to a lack of studies assessing the safety and effectiveness of statins for people in this age group. "There are no clear guidelines after 75,” says cardiologist Dara Lee Lewis, M.D., an associate physician and instructor in medicine at Brigham and Women's Hospital in Boston. “And it has been difficult as a provider, … how to say cheers in greek language

Lipid modification - CVD prevention Health topics A to Z CKS

Web3 de jun. de 2013 · Meta-analyses suggest that 80% of the lipid-lowering effect of statins occurs at half the maximal statin dose. 11 In older patients, the efficacy of statins for … Web18 de mar. de 2024 · Statins are drugs that can lower your cholesterol. They work by blocking a substance your body needs to make cholesterol. Lowering cholesterol isn't the … northgate ankeny iaWeb3 de mai. de 2024 · The recommended dose is: 30. Five-year CVD risk 5–15%: 10–20 mg atorvastatin (max 80 mg daily) Five-year CVD risk > 15% (including those with known CVD): 10–40 mg atorvastatin (max 80 mg daily) It is recommended to monitor non-fasting lipids every six-to-twelve months until the desired target is reached. how to say cheers in hebrew

"Web1 FDA has revised the drug labels for simvastatin and Vytorin to include the new dosing restriction for the 80-mg dose. The labels for simvastatin, Vytorin, and Simcor were also revised to include ... " - High dose statins in elderly

High dose statins in elderly

Web26 de fev. de 2024 · The American College of Cardiology/American Heart Association (ACC/AHA) task force on clinical practice guidelines has updated its 2013 cholesterol … Web3 de abr. de 2024 · Importantly, however, the combination of moderate-intensity statins and ezetimibe was associated with lower rates of intolerance-related drug discontinuation or …

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WebFor primary prevention of CVD, high-intensity statin treatment (atorvastatin 20 mg daily) should be considered in people (without the need for a formal risk assessment): With … Web12 de abr. de 2024 · Moderate-intensity statin with ezetimibe combination therapy was associated with lower rates of intolerance-related drug discontinuation or dose reduction among patients aged ≥75 years (2.3% vs. 7.2%; p = 0.010) and those aged <75 years (5.2% vs. 8.4%; p < 0.001) (p for interaction = 0.159). Median LDL-C levels were 58 mg/dL in …

WebNHS medicines information on atorvastatin – what it's used for, side effects, dosage and who can take it. WebThis risk can be heightened by factors such as high cholesterol, diabetes and high blood pressure, even in those who are otherwise seemingly healthy.” “Previous clinical trials – …

Web19 de jul. de 2024 · A specific high-dose preparation (4 grams per day of icosapent ethyl or 1800 mg per day of highly purified EPA) has been found to reduce the risk of heart attack, stroke, need for stent of bypass surgery, and cardiac death when used with a statin in people who have mild hypertriglyceridemia (149 to 500 mg/dL) and either established … WebInitiate with a lower dose and avoid very high dose or high intensity statins if at increased risk of myotoxicity e.g. the elderly, severe renal impairment (eGFR<30), liver …

Web12 de mar. de 2024 · Khush KK, Waters DD, Bittner V, et al. Effect of high-dose atorvastatin on hospitalizations for heart failure: subgroup analysis of the Treating to New Targets (TNT) study. Circulation 2007; 115:576. Horwich TB, MacLellan WR, Fonarow GC. Statin therapy is associated with improved survival in ischemic and non-ischemic heart …

WebA recent retrospective cohort study that researched the impact of statins on older people with diabetes mellitus showed a small statin benefit in those 75 to 85 years of age. 9 … northgate animal hospital colorado springs how to say cheers in irishWeb2 de out. de 2024 · Statin drugs have been shown to reduce the risk of cardiovascular disease (CVD) in young and middle-aged adults. With older adults (those 75 and over), the benefits are less clear. But a recent study published in the European Heart Journal suggests that there is in fact a benefit to statin use in this older population. northgate apartments bossier city laWeb19 de dez. de 2024 · The MIRACL study looked at the effects of a high dose of Lipitor on 3086 patients in the hospital after angina or nonfatal MI and followed them for 16 weeks. 37 According to the abstract: ... My … north gate apartmentsWeb18 de mai. de 2024 · Given the compelling data supporting statin therapy in the high-risk elderly population, ... Jukema JW, de Craen AJ, Eisenberg MJ. Statins for secondary … northgate apartments burnet txWeb25 de set. de 2014 · High doses or high-potency statins in elderly people may not increase effectiveness, but may increase the risk of adverse effects such as muscle-related aches, pains and weakness. Hence, statin use in the elderly requires frequent review and consideration of their therapeutic goals, quality of life, risk–benefit ratio and life expectancy. northgate apartments college station texasWebthere seems no controversy in initiation of statins in patients for primary prevention up to 80 years of age. Elderly people are at highest risk of cardiovascular morbidity and mortality, … northgate ankara