Myc interactors
WebMyc (avian myelocytomatosis viral oncogene homolog) represents one of the most sought after drug targets in cancer. Myc transcription factor is an essential regulator of cell … Web29 sep. 2024 · MYC, as a well-known oncogene, plays essential roles in promoting tumor occurrence, development, invasion and metastasis in many kinds of solid tumors and hematologic neoplasms. In tumors, the low expression and the short half-life of Myc are reversed, cause tumorigenesis. And proteins that directly interact with different Myc …
Myc interactors
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Web6 apr. 2015 · The high-confidence MYC interactors identified by BioID are also much more enriched in chromatin-associated proteins (as annotated in the GO database), as … Web13 okt. 2024 · Focusing on interactors in cis, which dominates the MYC chromatin network (7, 8), we observed that the overlap in interactors present in three different technical …
WebTo validate the MYC-G9a interaction, we performed proximity ligation assays (PLAs) in MDAMB231 breast cancer cells. We observed significantly higher fluorescence signal in … WebInteractors, such as Max, TRRAP, and PTEF-b, provide mechanistic insight into Myc's transcriptional activities, while others, such as ubiquitin ligases, regulate the Myc protein …
Web22 mei 2024 · Pipeline to identify and validate MYC protein–protein interactions. (Top) BioID-based screening of proximal protein interactors (steps 1–3) can identify high … Web12 mei 2024 · Later, the same group identified protein phosphatase 1 (PP1) and its regulatory subunit protein phosphatase-1 nuclear-targeting subunit (PNUTS) as MYC …
Web10 jan. 2024 · A total of 1561 potential interactors were identified in MYC-bound immunoprecipitates, and 1469 in MYCN-bound ones, among which 1059 proteins (~70% of overlap) were common MYC and MYCN interactors ...
Web13 feb. 2016 · Abstract. N-myc & STAT Interactor, NMI, is a protein that has mostly been studied for its physical interactions with transcription factors that play critical roles in … together we rideWeb18 sep. 2015 · MYC protein interactors in gene transcription and cancer. 29 June 2024. Corey Lourenco, Diana Resetca, … Linda Z. Penn. MYC oncogene elicits tumorigenesis … people population in the worldWeb29 jun. 2024 · Other MYC interactors, such as transformation/transcription domain-associated protein (TRRAP) and TIP60, also contribute in priming the chromatin … together we rise skateboard instructionsWeb14 mrt. 2024 · Her lab is also pursuing other ways to target Myc, such as finding ways to stabilize a homodimer of two Myc molecules, which would likely end up being degraded … together we rise by ravenwolfWeb1 jan. 2024 · Summary. c-MYC controls global gene expression and regulates cell proliferation, cell differentiation, cell cycle, metabolism and apoptosis. According to some … people/populationWeb27 mrt. 2024 · Transforming members of the MYC family (MYC, MYCL1, MYCN) encode transcription factors containing six highly conserved regions, termed MYC homology … together we rise charity ratingWebWe also discuss methods used to screen for Myc interactors and provide an in silico strategy to help prioritize hits for further validation using the described Co-IP and in vitro … together we rise birthday boxes